Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 125
Filtrar
1.
Preprint em Português | SciELO Preprints | ID: pps-8362

RESUMO

Introduction: In December 2019, the first cases of COVID-19 emerged in China and in March 2020, the WHO declared COVID-19 as the second pandemic of the 21st century. As a measure to contain the spread of the disease, social isolation was recommended. Numerous studies have pointed to an increase in stress symptoms related to the pandemic. It is known that medical students are more susceptible to responding to stressful situations in a non-adaptive way. Objectives: To evaluate the perceived stress level of medical students in 2019 and 2020, periods before and during the COVID-19 pandemic. Assess the level of stress in the middle and end (exam season) of the second semester of 2020, during the COVID-19 pandemic. Methods: The PSS-14 - Perceived Stress Scale was applied to medical students from the second to the eighth period of the Medicine course at Faculdade Evangélica Mackenzie do Paraná, in 2019 and 2020, through an online questionnaire. Results: In 2019, a total of 158 students participated in the two phases (beginning and end of the first semester) of the study. The average age was 22.2 years old and 57.6% were female. In 2020, a total of 42 students participated in the two phases (half and end of the second semester) of the study. The average age was 23.3 years old and 69% were female. When comparing the PSS 14 scale scores in the two assessments, the levels were lower in 2020. Conclusions: The perceived stress level of medical students was lower during the pandemic period compared to the pre-pandemic period. There was no difference in the assessment of perceived stress when comparing the middle and end of the 2020 semester.


Introdução: Em dezembro de 2019 surgiram na China os primeiros casos de COVID-19 e em março de 2020 a OMS declarou a COVID-19 como a segunda pandemia do século 21.  Como medida para conter a disseminação da doença, recomendou-se o isolamento social. Inúmeros estudos apontaram para aumento de sintomas de estresse relacionados à pandemia. Sabe-se que estudantes de Medicina estão mais suscetíveis a responder às situações estressantes de modo não adaptativo. Objetivos: Avaliar o nível de estresse percebido dos estudantes de medicina em 2019 e 2020, períodos pré e durante a pandemia de COVID-19. Avaliar o nível de estresse na metade e final (época de provas) do segundo semestre de 2020, durante a pandemia de COVID-19.  Métodos: Foi aplicada a Escala de Estresse Percebido PSS-14 aos alunos de Medicina do segundo ao oitavo período do curso de Medicina da Faculdade Evangélica Mackenzie do Paraná, em 2019 e 2020, através de questionário online. Resultados: Em 2019, participaram das duas fases (início e final do primeiro semestre) do estudo um total de 158 alunos. A média de idade foi de 22,2 anos e 57,6% eram do sexo feminino. Em 2020, participaram das duas fases (metade e final do segundo semestre) do estudo um total de 42 alunos. A média de idade foi de 23,3 anos e 69% eram do sexo feminino. Na comparação entre os escores da escala PSS 14 nas duas avaliações, os níveis foram menores em 2020. Conclusões: O nível de estresse percebido dos estudantes de medicina foi menor no período de pandemia em comparação ao período pré-pandemia. Não houve diferença na avaliação do estresse percebido na comparação entre o período da metade e do final do semestre de 2020.

2.
Biosens Bioelectron ; 255: 116210, 2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38537427

RESUMO

Viral respiratory infections represent a major threat to the population's health globally. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 disease and in some cases the symptoms can be confused with Influenza disease caused by the Influenza A viruses. A simple, fast, and selective assay capable of identifying the etiological agent and differentiating the diseases is essential to provide the correct clinical management to the patient. Herein, we described the development of a genomagnetic assay for the selective capture of viral RNA from SARS-CoV-2 and Influenza A viruses in saliva samples and employing a simple disposable electrochemical device for gene detection and quantification. The proposed method showed excellent performance detecting RNA of SARS-CoV-2 and Influenza A viruses, with a limit of detection (LoD) and limit of quantification (LoQ) of 5.0 fmol L-1 and 8.6 fmol L-1 for SARS-CoV-2, and 1.0 fmol L-1 and 108.9 fmol L-1 for Influenza, respectively. The genomagnetic assay was employed to evaluate the presence of the viruses in 36 saliva samples and the results presented similar responses to those obtained by the real-time reverse transcription-polymerase chain reaction (RT-PCR), demonstrating the reliability and capability of a method as an alternative for the diagnosis of COVID-19 and Influenza with point-of-care capabilities.


Assuntos
Técnicas Biossensoriais , COVID-19 , Vírus da Influenza A , Influenza Humana , Humanos , SARS-CoV-2/genética , COVID-19/diagnóstico , Vírus da Influenza A/genética , Influenza Humana/diagnóstico , Saliva , Reprodutibilidade dos Testes
3.
Oral Dis ; 2024 Feb 29.
Artigo em Inglês | MEDLINE | ID: mdl-38424685

RESUMO

AIM: To assess the immediate and late effects of the COVID-19 pandemic on the oral health-related quality of life (OHRQoL) of adolescents. DESIGN: This is a longitudinal study performed with adolescents (11-15 years old) from Southern Brazil who were evaluated before the COVID-19 outbreak, and 3 (T2) and 15 (T3) months after the beginning of the pandemic. OHRQoL was assessed using the CPQ11-14. Sociodemographic and clinical variables were also collected. Changes in OHRQoL before, 3 and 15 months after the start of the pandemic were analyzed through multilevel Poisson regression models for repeated measures. RESULTS: A total of 290 adolescents were evaluated at T1, 207 were re-evaluated at T2, and 204 at T3. Overall CPQ11-14 scores over follow-ups were 11.0 (SD 8.0) at T1, 8.3 (SD 7.8) and 12.8 (SD 8.8) at T3. Compared to T1, adolescents presented 29% lower overall CPQ11-14 scores (IRR 0.71 95% CI 0.66-0.75) at T2, and 11% higher scores at T3 (IRR 1.11 95% CI 1.05-1 0.17), especially for the emotional and social well-being domains. CONCLUSION: COVID-19 pandemic impacted the adolescents' OHRQoL differently over time, indicating a reduction in impacts immediately after the beginning and worsening over long term exposure to this scenario.

4.
Nat Commun ; 15(1): 2679, 2024 Mar 27.
Artigo em Inglês | MEDLINE | ID: mdl-38538644

RESUMO

In 2015, we launched the mesoSPIM initiative, an open-source project for making light-sheet microscopy of large cleared tissues more accessible. Meanwhile, the demand for imaging larger samples at higher speed and resolution has increased, requiring major improvements in the capabilities of such microscopes. Here, we introduce the next-generation mesoSPIM ("Benchtop") with a significantly increased field of view, improved resolution, higher throughput, more affordable cost, and simpler assembly compared to the original version. We develop an optical method for testing detection objectives that enables us to select objectives optimal for light-sheet imaging with large-sensor cameras. The improved mesoSPIM achieves high spatial resolution (1.5 µm laterally, 3.3 µm axially) across the entire field of view, magnification up to 20×, and supports sample sizes ranging from sub-mm up to several centimeters while being compatible with multiple clearing techniques. The microscope serves a broad range of applications in neuroscience, developmental biology, pathology, and even physics.


Assuntos
Microscopia , Neurociências , Microscopia/métodos
5.
Med. oral patol. oral cir. bucal (Internet) ; 29(1): e78-e86, Ene. 2024. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-229191

RESUMO

Background: Lymphomas affecting the submandibular glands are very uncommon and few reports are currentlyavailable in the literature. Therefore, the aim of the current study is to describe the clinical and microscopic fea-tures of an original series of lymphomas affecting the submandibular glands.Material and Methods: The pathology files of two institutions were searched for lymphoma cases affecting thesubmandibular glands. The original hematoxylin and eosin, and immunohistochemical slides were revised by apathologist for diagnosis confirmation following the revised 4th edition of the World Health Organization classification of tumours of haematopoietic and lymphoid tissues. Clinical data regarding age, sex, clinical manifestation,treatment, follow-up and status at last appointment were retrieved from the patients’ medical charts.Results: During the period investigated, 16 cases were included in the study. Females predominated (10:6) with amean age of 57.8 years-old. Tumors usually presented as asymptomatic swellings. MALT lymphoma representedthe most common subtype, followed by diffuse large B cell lymphoma and follicular lymphoma. Three patientsdied, one of them affected by plasmablastic lymphoma, one by DLBCL and one by MALT lymphoma.Conclusions: Low-grade B cell lymphomas predominate in the submandibular glands, but DLBCL and other sub-types may also be rarely diagnosed in this salivary gland.(AU)


Assuntos
Humanos , Masculino , Feminino , Linfoma Folicular , Linfoma , Glândulas Salivares , Glândula Submandibular , Linfoma de Zona Marginal Tipo Células B
6.
Qual Life Res ; 33(1): 219-227, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-37582819

RESUMO

PURPOSE: This study aimed to evaluate the association of oral health literacy (OHL) and oral health-related quality of life (OHRQoL) of pregnant women. METHODS: This cross-sectional study evaluated a representative sample of pregnant women assisted in public health services in southern Brazil. Demographic, socioeconomic, psychosocial and behavioural data were collected through structured questionnaires. The Oral Health Impact Profile (OHIP-14) questionnaire was used to evaluate the OHRQoL. The Brazilian Rapid Estimate of Adult Literacy in Dentistry (BREALD-30) was used to measure OHL. Dental caries and gingival bleeding were evaluated by clinical examinations. Adjusted multilevel Poisson regression models with a hierarchical approach were used to assess the associations. The results are presented as rate ratio (RR) and 95% confidence interval (95% CI). RESULTS: A total of 520 pregnant women were evaluated. Pregnant women with lower levels of OHL presented overall OHIP-14 scores 14% higher (RR 1.14; 95% CI 1.07-1.22) than their counterparts. High household income and high education level were related to low overall OHIP-14 scores. Furthermore, less dental attendance, low social support, untreated dental caries and gingival bleeding were also associated with high overall OHIP-14 scores. CONCLUSION: Our findings reinforce that health literacy levels influence patient-reported outcomes. Pregnant women with lower OHL were more likely to present poorer OHRQoL.


Assuntos
Cárie Dentária , Letramento em Saúde , Adulto , Humanos , Feminino , Gravidez , Saúde Bucal , Gestantes , Qualidade de Vida/psicologia , Estudos Transversais , Inquéritos e Questionários , Brasil
7.
Biomedicines ; 11(12)2023 Dec 18.
Artigo em Inglês | MEDLINE | ID: mdl-38137569

RESUMO

Curcumin is a highly promising substance for treating burns, owing to its anti-inflammatory, antioxidant, antimicrobial, and wound-healing properties. However, its therapeutic use is restricted due to its hydrophobic nature and low bioavailability. This study was conducted to address these limitations; it developed and tested two types of lipid nanocarriers, namely nanoemulsions (NE-CUR) and nanostructured lipid carriers (NLC-CUR) loaded with curcumin, and aimed to identify the most suitable nanocarrier for skin burn treatment. The study evaluated various parameters, including physicochemical characteristics, stability, encapsulation efficiency, release, skin permeation, retention, cell viability, and antimicrobial activity. The results showed that both nanocarriers showed adequate size (~200 nm), polydispersity index (~0.25), and zeta potential (~>-20 mV). They also showed good encapsulation efficiency (>90%) and remained stable for 120 days at different temperatures. In the release test, NE-CUR and NCL-CUR released 57.14% and 51.64% of curcumin, respectively, in 72 h. NE-CUR demonstrated better cutaneous permeation/retention in intact or scalded skin epidermis and dermis than NLC-CUR. The cell viability test showed no toxicity after treatment with NE-CUR and NLC-CUR up to 125 µg/mL. Regarding microbial activity assays, free curcumin has activity against P. aeruginosa, reducing bacterial growth by 75% in 3 h. NE-CUR inhibited bacterial growth by 65% after 24 h, and the association with gentamicin had favorable results, while NLC-CUR showed a lower inhibition. The results demonstrated that NE-CUR is probably the most promising nanocarrier for treating burns.

8.
Braz Oral Res ; 37: e108, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37970928

RESUMO

This study investigated the prevalence of possible bruxism and its association with social capital among undergraduates during the coronavirus disease (COVID-19) pandemic. This cross-sectional study was conducted at a private university in Southern Brazil. Data were collected through a self-administered electronic questionnaire (Google Forms). Possible bruxism was measured using the following question: "Do you grind your teeth or clench your jaws?". Social capital was evaluated using individual social networks. Data on self-perceived oral health, anxiety, sociodemographics, and information related to university graduates were also collected. Adjusted logistic regression models with a hierarchical approach were used to evaluate associations. The results are presented as odds ratios (ORs) and 95% confidence intervals (95%CIs). Altogether, 345 undergraduates participated in the study, with a mean age of 21.8 years (standard deviation = 5.21). The prevalence of bruxism in the sample was 57.1%. Undergraduates with low social capital had 2.06 times greater odds of bruxism than their counterparts (OR 2.06; 95%CI 1.11-3.83). Female undergraduates (OR 2.40, 95%CI 1.39-4.12), those who were in the final year of university (OR 1.13, 95%CI 1.04-1.21), and those who perceived they needed dental treatment (OR 1.91; CI: 1.21-3.02) also had greater odds of possible bruxism. In conclusion, the prevalence of possible bruxism was high among undergraduate students during the COVID-19 pandemic and associated with lower social capital levels. Knowledge of these factors is important to identify risk groups and plan strategies to control bruxism in this population.


Assuntos
Bruxismo , COVID-19 , Capital Social , Humanos , Feminino , Adulto Jovem , Adulto , Bruxismo/epidemiologia , Brasil/epidemiologia , Pandemias , Estudos Transversais , COVID-19/epidemiologia , Estudantes , Inquéritos e Questionários
9.
Oral Dis ; 2023 Sep 27.
Artigo em Inglês | MEDLINE | ID: mdl-37759359

RESUMO

AIM: To evaluate the immediate and late impact of the COVID-19 pandemic on the occurrence of possible sleep bruxism (SB) among adolescents in Brazil. DESIGN: This is a longitudinal study performed with adolescents (11-15 years old) from Southern Brazil. Baseline data were collected before the Brazilian COVID-19 outbreak (T1). Posteriorly, data were collected after 3 (T2) and 15 months under the Brazilian COVID-19 outbreak. The possible SB was evaluated by the question: 'Do you grind your teeth during your sleep?'. Sociodemographic, psychosocial and clinical variables were also collected. Changes in SB were evaluated by multilevel logistic regression models for repeated measures. RESULTS: Of the 290 adolescents assessed at T1, 182 were reassessed at both follow-ups. The prevalence of possible SB was 13% at T1, 11% at T2 and 22% at T3. There were no immediate effects of the COVID-19 pandemic on the occurrence of possible SB (T2). Adolescents had odds 2.77 times greater of presented possible SB after 15 months (T3) of COVID-19 pandemic scenarios when compared to T1. CONCLUSION: There was a considerable and late increase in the possible SB in adolescents in Brazil during the COVID-19 pandemic.

10.
J Prosthet Dent ; 2023 Sep 08.
Artigo em Inglês | MEDLINE | ID: mdl-37690857

RESUMO

STATEMENT OF PROBLEM: The success rate of monolithic polymer-infiltrated ceramic posterior crowns after 1 year is unclear. PURPOSE: The purpose of this controlled, randomized, and double-blind clinical trial was to evaluate the performance of posterior complete crowns in polymer-infiltrated and lithium disilicate ceramics and to assess the impact of oral rehabilitation on esthetic satisfaction, quality of life, and periodontal health. MATERIAL AND METHODS: A total of 33 crowns were provided in 18 participants allocated to 2 groups: Control (Lithium disilicate-IPS e.max CAD; Ivoclar AG) and Experimental (Polymer-infiltrated ceramic-Vita Enamic; Vita Zahnfabrik). The crowns were evaluated before treatment (T0) and after 1 (T1), 6 (T2), and 12 (T3) months by using modified United States Public Health Service (USPHS) criteria, visual analog scales (VASs), oral impacts on daily performances (OIDP), and periodontal parameters. Survival analysis was performed by using Kaplan-Meier followed by the log-rank test (α=.05). The OIDP and USPHS data were analyzed descriptively while VASs for esthetic satisfaction and periodontal parameters were statistically evaluated by using the Mann-Whitney Friedman, and Wilcoxon post hoc tests. RESULTS: For 18 participants with a mean age of 47.2 years, 19 crowns were manufactured in lithium disilicate and 14 in polymer-infiltrated ceramic. The Kaplan-Meier test revealed similar survival rates of 92.5% for polymer-infiltrated ceramic and 94.7% for lithium disilicate (P>.05). The analysis of periodontal parameters revealed a significant increase in the bleeding on probing (BOP) for polymer-infiltrated ceramics (P=.032) but for lithium disilicate, it was not significant (P=.387). CONCLUSIONS: Survival rates between the evaluated materials were not significantly different, with acceptable clinical performance after 1 year of follow-up.

11.
Mem Inst Oswaldo Cruz ; 118: e230071, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37729273

RESUMO

BACKGROUND: Leishmania RNA virus 1 (LRV1) is commonly found in South American Leishmania parasites belonging to the subgenus Viannia, whereas Leishmania RNA virus 2 (LRV2) was previously thought to be restricted to the Old-World pathogens of the subgenus Leishmania. OBJECTIVES: In this study, we investigated the presence of LRV2 in strains of Leishmania (L.) infantum, the causative agent of visceral leishmaniasis (VL), originating from different hosts, clinical forms, and geographical regions. METHODS: A total of seventy-one isolates were screened for LRV2 using semi-nested reverse transcription-polymerase chain reaction (RT-PCR) targeting the RNA-dependent RNA polymerase (RdRp) gene. FINDINGS: We detected LRV2 in two L. infantum isolates (CUR268 and HP-EMO) from canine and human cases, respectively. MAIN CONCLUSIONS: To the best of our knowledge, this is the first detection of LRV2 in the New World.


Assuntos
Leishmania infantum , Leishmaniose Visceral , Humanos , Animais , Cães , Leishmania infantum/genética , Leishmaniose Visceral/veterinária , Brasil , RNA Polimerase Dependente de RNA
12.
Angiol. (Barcelona) ; 75(4): 242-258, Juli-Agos. 2023. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-223704

RESUMO

El pie diabético (PD) representa una de las complicaciones crónicas de la enfermedad diabética, que se debe a alteraciones estructurales y funcionales del pie, lo que provoca, entre otros efectos, las úlceras del pie diabético (UPD). Las tasas de mortalidad asociadas con el desarrollo de una UPD se estiman en un 5 % en el primer año y en un 42 % a los cinco años. A menudo puede identificarse un evento iniciador potencialmente prevenible, como un traumatismo menor que causa una lesión cutánea. La presentación clásica de la UPD es la de un pie infectado grave a través de una herida previa, con necrosis rápidamente progresiva. Se observa un tejido necrótico y colecciones purulentas. Las amputaciones del pie, muchas de las cuales pueden prevenirse con un reconocimiento y un tratamiento tempranos, pueden ser necesarias en hasta el 20 % de las úlceras del pie diabético. Los exámenes de detección sistemáticos para la afectación neuropática y vascular de las extremidades inferiores y la inspección cuidadosa de los pies pueden reducir sustancialmente la morbilidad de los problemas de los pies. El tratamiento efectivo de las UPD es complejo y requiere un gasto considerable de recursos y un costo significativo para el sistema de atención médica. En la presente revisión se hace una descripción de la fisiopatología, epidemiología, presentación clínica, diagnóstico y tratamiento de la UPD.(AU)


The diabetic foot (PD) represents one of the chronic complications of diabetic disease, which occurs due to structur-al and functional alterations of the foot, causing, among others, diabetic foot ulcers (DFU). Mortality rates associatedwith the development of a DFU are estimated at 5 % in the first year, and 42 % at five years. A potentially preventableinitiating event can often be identified, such as minor trauma causing a skin lesion. The classic presentation of DFUis that of a severely infected foot through a previous wound, with rapidly progressive necrosis, necrotic tissue andpurulent collections are observed. Foot amputations, many of which can be prevented with early recognitionand treatment, may be required in up to 20 % of diabetic foot ulcers. Routine screening for neuropathic and vascularinvolvement of the lower extremities and careful inspection of the feet can substantially reduce the morbidity offoot problems. Effective treatment of DFUs is complex and requires considerable expenditure of resources andsignificant cost to the health care system. This review provides a description of the pathophysiology, epidemiology,clinical presentation, diagnosis, and treatment of DFU.(AU)


Assuntos
Humanos , Masculino , Feminino , Pé Diabético/diagnóstico , Pé Diabético/tratamento farmacológico , Pé Diabético/terapia , Pé Diabético/mortalidade , Complicações do Diabetes
13.
Artigo em Inglês | LILACS | ID: biblio-1442402

RESUMO

The human sensory receptors are morphologically specialized to transduce specific stimuli into the brain. However, when an injury occurs, mainly in the spinal cord, which can be of traumatic or non-traumatic origin, it provokes various degrees of sensory deficits, autonomic, motor and sphincter dysfunction below the level of the injury. Based on this, a new therapeutic modality is being proposed by neuroscientist Miguel Nicolelis, which is based on the brain-machine interface, that is, using other pathways so that the information can reach the cerebral cortex and thus be consciously processed (AU).


Os receptores sensoriais humanos são morfologicamente especializados para realizar a transdução de estímulos específicos para o encéfalo. Entretanto, quando ocorre uma lesão, principalmente, na medula espinal, que pode ser de origem traumática e não traumática, provocam diversos graus de déficits sensoriais, disfunção autônoma, motora e esfincteriana, abaixo do nível da lesão. Com base nisso, uma nova modalidade terapêutica está sendo proposto pelo neurocientista Miguel Nicolelis, que tem como base a interface cérebro máquina, isto é, utilizar-se de outras vias para que as informações possam chegar no córtex cerebral e assim serem processadas conscientemente.Palavras-chave: Interfaces cérebro-computador, Neurociências, Órgãos dos sentidos (AU).


Assuntos
Órgãos dos Sentidos , Neurociências , Interfaces Cérebro-Computador
15.
Int J Pharm ; 635: 122712, 2023 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-36803927

RESUMO

Burns affect the skin and appendages, impair their function, and become favorable regions for bacterial infections. Owing to time-consuming and costly treatments, burns have been considered a public health problem. The limitations of the treatments used for burns have motivated the search for more efficient alternatives. Curcumin has several potential properties such as anti-inflammatory, healing, and antimicrobial activities. However, this compound is unstable and has low bioavailability. Therefore, nanotechnology could offer a solution for its application. This study aimed to develop and characterize dressings (or gauzes) impregnated with curcumin nanoemulsions that were prepared using two different techniques as a promising platform for skin burn treatment. In addition, the effect of cationization on curcumin release from the gauze was evaluated. Nanoemulsions were successfully prepared using two methods, ultrasound and a high-pressure homogenizer, with sizes of 135 nm and 144.55 nm, respectively. These nanoemulsions exhibited a low polydispersity index, adequate zeta potential, high encapsulation efficiency, and stability for up to 120 d. In vitro assays demonstrated a controlled release of curcumin between 2 and 240 h. No cytotoxicity was observed at concentrations of curcumin up to 75 µg/mL, and cell proliferation was observed. The incorporation of nanoemulsions in the gauze was successfully achieved, and the evaluation of curcumin release showed a faster release from cationized gauzes, whereas the non-cationized gauze promoted a more constant release.


Assuntos
Queimaduras , Curcumina , Humanos , Curcumina/farmacologia , Administração Cutânea , Cicatrização , Nanotecnologia , Queimaduras/tratamento farmacológico
16.
Head Neck Pathol ; 17(1): 154-164, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-36166159

RESUMO

BACKGROUND: Lymphomas affecting the sublingual glands are extremely rare and very few case reports are currently available. Therefore, the aim of the current study is to describe the clinicopathological features of a series of lymphomas involving the sublingual glands. METHODS: Cases diagnosed in four pathology services were assessed and the formalin-fixed paraffin-embedded tissue blocks were retrieved for diagnosis confirmation. Clinical data were obtained from patients' medical files. RESULTS: We obtained seven cases of lymphomas in the sublingual glands, representing two follicular lymphomas, two diffuse large B cell lymphomas not otherwise specified (DLBCL NOS), two extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphomas) and one mantle cell lymphoma (MCL). In all cases the tumor cells infiltrated the glandular parenchyma, although in two of them the neoplastic cells were located more superficially and permeated the glandular acini and ducts. Clinically, the tumors presented as asymptomatic nodules and two patients (affected by DLBCL NOS and MCL) died, while the other five patients remained alive at last follow-up. CONCLUSION: Lymphomas affecting the sublingual glands are usually of the mature B cell lineage, often represent low-grade subtypes and may clinically resemble other more common lesions in the floor of the mouth like salivary gland tumors.


Assuntos
Linfoma de Zona Marginal Tipo Células B , Linfoma Folicular , Linfoma Difuso de Grandes Células B , Linfoma de Célula do Manto , Neoplasias das Glândulas Salivares , Adulto , Humanos , Glândula Sublingual/patologia , Linfoma de Zona Marginal Tipo Células B/patologia , Linfoma Difuso de Grandes Células B/patologia , Neoplasias das Glândulas Salivares/patologia
17.
Mem. Inst. Oswaldo Cruz ; 118: e230071, 2023. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1514607

RESUMO

BACKGROUND Leishmania RNA virus 1 (LRV1) is commonly found in South American Leishmania parasites belonging to the subgenus Viannia, whereas Leishmania RNA virus 2 (LRV2) was previously thought to be restricted to the Old-World pathogens of the subgenus Leishmania. OBJECTIVES In this study, we investigated the presence of LRV2 in strains of Leishmania (L.) infantum, the causative agent of visceral leishmaniasis (VL), originating from different hosts, clinical forms, and geographical regions. METHODS A total of seventy-one isolates were screened for LRV2 using semi-nested reverse transcription-polymerase chain reaction (RT-PCR) targeting the RNA-dependent RNA polymerase (RdRp) gene. FINDINGS We detected LRV2 in two L. infantum isolates (CUR268 and HP-EMO) from canine and human cases, respectively. MAIN CONCLUSIONS To the best of our knowledge, this is the first detection of LRV2 in the New World.

18.
Braz. oral res. (Online) ; 37: e108, 2023. tab, graf
Artigo em Inglês | LILACS-Express | LILACS, BBO - Odontologia | ID: biblio-1520523

RESUMO

Abstract This study investigated the prevalence of possible bruxism and its association with social capital among undergraduates during the coronavirus disease (COVID-19) pandemic. This cross-sectional study was conducted at a private university in Southern Brazil. Data were collected through a self-administered electronic questionnaire (Google Forms). Possible bruxism was measured using the following question: "Do you grind your teeth or clench your jaws?". Social capital was evaluated using individual social networks. Data on self-perceived oral health, anxiety, sociodemographics, and information related to university graduates were also collected. Adjusted logistic regression models with a hierarchical approach were used to evaluate associations. The results are presented as odds ratios (ORs) and 95% confidence intervals (95%CIs). Altogether, 345 undergraduates participated in the study, with a mean age of 21.8 years (standard deviation = 5.21). The prevalence of bruxism in the sample was 57.1%. Undergraduates with low social capital had 2.06 times greater odds of bruxism than their counterparts (OR 2.06; 95%CI 1.11-3.83). Female undergraduates (OR 2.40, 95%CI 1.39-4.12), those who were in the final year of university (OR 1.13, 95%CI 1.04-1.21), and those who perceived they needed dental treatment (OR 1.91; CI: 1.21-3.02) also had greater odds of possible bruxism. In conclusion, the prevalence of possible bruxism was high among undergraduate students during the COVID-19 pandemic and associated with lower social capital levels. Knowledge of these factors is important to identify risk groups and plan strategies to control bruxism in this population.

19.
Rev. Nutr. (Online) ; 36: e220106, 2023. tab
Artigo em Inglês | LILACS | ID: biblio-1507421

RESUMO

ABSTRACT Objective To evaluate the food practices and nutritional status of students who use the University Restaurant at a public university. Methods This is a cross-sectional study carried out with 958 university students. Data related to regular eating practices (≥5 times/week), routine food consumption and nutritional status were collected. The association between University Restaurant attendance and dietary practices and body mass index was reviewed by bivariate logistic regression model and multiple regression. Results Students who attended the University Restaurant three or more times a week were more likely to regularly consume beans (OR: 1.35, p=0.041) and fresh salad (OR: 1.77, p<0.001) and less likely to have afternoon snack (OR: 0.68; p=0.008). In addition, an association between soda consumption and overweight was observed. Conclusion Thus, the importance of strategies that seek to promote incentives for healthy eating and lifestyle practices in the university population become evident.


RESUMO Objetivo O objetivo do estudo foi avaliar as práticas alimentares e o estado nutricional de estudantes usuários do restaurante-escola em uma universidade pública. Métodos Trata-se de um estudo transversal realizado com 958 estudantes universitários. Foram coletados dados relacionados às práticas alimentares regulares (≥5 vezes/semana), à rotina alimentar e ao estado nutricional. A associação entre a frequência de ida ao restaurante-escola, práticas alimentares e índice de massa corporal foi analisada por modelo de regressão logística bivariada e regressão múltipla. Resultados Os estudantes que frequentaram o restaurante-escola 3 ou mais vezes por semana apresentaram maiores chances de consumir regularmente feijão (OR: 1,35, p=0,041) e salada crua (OR: 1,77, p<0,001) e menos chances de realizar o lanche da tarde (OR: 0,68; p=0,008). Além disso, foi observada associação entre o consumo de refrigerante e o excesso de peso. Conclusão Dessa forma, evidencia-se a importância de estratégias que busquem promover incentivos a práticas alimentares e de vida saudáveis na população universitária.


Assuntos
Humanos , Masculino , Feminino , Adulto , Adulto Jovem , Estudantes , Estado Nutricional/fisiologia , Ingestão de Alimentos/etnologia , Restaurantes , Universidades , Índice de Massa Corporal , Estudos Transversais , Sobrepeso/epidemiologia , Bebidas Adoçadas com Açúcar/efeitos adversos
20.
Rev. enferm. atenção saúde ; 12(3): 2023101, jul.-out. 2023. tab
Artigo em Inglês, Espanhol, Português | BDENF - Enfermagem | ID: biblio-1509942

RESUMO

Objetivo: Identificar conhecimentos, atitudes e práticas frente à COVID-19 de idosos que vivem na comunidade. Metodologia: Trata-se de um estudo transversal analítico, a população constitui-se de idosos acompanhados por uma Estratégia de Saúde da Família, os instrumentos utilizados foram: perfil sociodemográfico e o CAP (Conhecimentos, Atitudes e Práticas). Resultados: Participaram do estudo 89 idosos, com média de idade de 68,96 anos, com predominância do sexo feminino. Ao serem indagados se o contato humano ou alimentar-se de animais silvestres transmite à COVID-19, 34,8% (n=31) responderam sim, já sobre as medidas de prevenção, 97,8% (n=87) concordam ser necessário utilizar máscara para evitar a contaminação pelo novo coronavírus. A maioria dos idosos 85,4% (n=76) apresentaram esperança sobre o fim da pandemia. Conclusão: A maioria dos idosos conhece, tem atitudes positivas e adotam práticas de controle da transmissão da COVID-19 (AU).


Objective: Identify the elderly knowledge, attitudes and practices regarding COVID-19, in the community. Methodology: It is an analytic cross-sectional study, having the elderly population as a target. A Family Health Strategy Program assisted them and, the criteria applied were: Sociodemographic profile; The CAP (which stands for Knowledge, Attitudes and Practices ­ KAP). Results: 89 elderly individuals were taken into the study, with ages ranging from 68 to 96 years old and predominantly female. When asked if human contact and eating wild animals meat would transmit the COVID-19 virus, 34,8% (n= 31) have answered "yes". In regards to preventive measures, 97,8% (n=87) have agreed that using masks is necessary to avoid contamination from the new Coronavirus. The majority of them, 85.4% (n=76) have shown themselves hopeful towards the end of the pandemic. Conclusion: The majority of elderly people not only know about the disease but also have positive attitudes and adopt practices to control the COVID-19 contamination (AU).


Objetivo: Identificar conocimientos, actitudes y prácticas frente al COVID-19 de los adultos mayores que viven en la comunidad. Metodología: Se trata de un estudio transversal analítico, la población está constituida por adultos mayores acompañados de una Estrategia de Salud de la Familia, los instrumentos utilizados fueron: sociodemográficos perfil y CAP (Conocimientos, Actitudes y Prácticas). Resultados: Participaron del estudio 89 ancianos, con una edad media de 68,96 años, con predominio del sexo femenino. Ante la pregunta de si el contacto humano o comer animales silvestres transmite el COVID-19, el 34,8 % (n=31) respondió que sí, mientras que en cuanto a las medidas de prevención, el 97,8 % (n=87) está de acuerdo en que es necesario usar mascarilla para evitar el contagio. por el nuevo coronavirus. La mayoría de los adultos mayores 85,4% (n=76) mostró esperanza en el fin de la pandemia. Conclusión: La mayoría de los ancianos conocen, tienen actitudes positivas y adoptan prácticas para controlar la transmisión de la COVID-19 (AU).


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Idoso , Conhecimentos, Atitudes e Prática em Saúde , COVID-19
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...